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Creators/Authors contains: "Pugno, Nicola M"

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  1. Ongoing efforts seek to unravel theories that can make simple, quantitative and reasonably accurate predictions of the morphological adaptive changes that arise with the size variation. Yet, relatively scant attention has been directed towards lateral undulatory locomotion. In the current study, we explore: (i) the constraints imposed by the variation of length and mass in viscous and dry friction environments on the cost of transport (COT) of lateral undulatory locomotion and (ii) the role of the body, environment and input oscillations in such an intricate interplay. In a dry friction environment, minimum COT correlates with stiffer and longer bodies, higher frictional anisotropy and angular amplitudes greater than approximately 10o. Conversely, a viscous environment favours flexible long bodies, higher frictional anisotropy and angular amplitudes lower than approximately 30o. In both environments, optimizing mass and maintaining low angular frequencies minimizes COT. Our conclusions are applicable only in the low-Reynolds-number regime, and it is essential to consider the interdependence of parameters when applying the generalized results. Our findings highlight musculoskeletal and biomechanical adaptations that animals may use to mitigate the consequences of size variation and to meet the energetic demands of lateral undulatory locomotion. These insights enhance foundational biomechanics knowledge while offering practical applications in robotics and ecology. 
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    Free, publicly-accessible full text available April 1, 2026
  2. The last years have witnessed remarkable advances in our understanding of the emergence and consequences of topological constraints in biological and soft matter. Examples are abundant in relation to (bio)polymeric systems and range from the characterization of knots in single polymers and proteins to that of whole chromosomes and polymer melts. At the same time, considerable advances have been made in the description of the interplay between topological and physical properties in complex fluids, with the development of techniques that now allow researchers to control the formation of and interaction between defects in diverse classes of liquid crystals. Thanks to technological progress and the integration of experiments with increasingly sophisticated numerical simulations, topological biological and soft matter is a vibrant area of research attracting scientists from a broad range of disciplines. However, owing to the high degree of specialization of modern science, many results have remained confined to their own particular fields, with different jargon making it difficult for researchers to share ideas and work together towards a comprehensive view of the diverse phenomena at play. Compelled by these motivations, here we present a comprehensive overview of topological effects in systems ranging from DNA and genome organization to entangled proteins, polymeric materials, liquid crystals, and theoretical physics, with the intention of reducing the barriers between different fields of soft matter and biophysics. Particular care has been taken in providing a coherent formal introduction to the topological properties of polymers and of continuum materials and in highlighting the underlying common aspects concerning the emergence, characterization, and effects of topological objects in different systems. The second half of the review is dedicated to the presentation of the latest results in selected problems, specifically, the effects of topological constraints on the viscoelastic properties of polymeric materials; their relation with genome organization; a discussion on the emergence and possible effects of knots and other entanglements in proteins; the emergence and effects of topological defects and solitons in complex fluids. This review is dedicated to the memory of Marek Cieplak. 
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